Although there are no specific medications to treat meth addiction, other medications can help to:
- Decrease craving
- Ease withdrawal symptoms
- Decrease meth drug seeking and use
- Improve sleep, energy and focus
- Stabilize mood
Do They Work?
Modafinil, bupropion and naltrexone show positive results.
- Modafinil helps treat mood changes from meth withdrawal and ease withdrawal symptoms. It may also decrease cravings and the need to seek out the drug.
- Bupropion may help men with low to moderate meth dependence stay drug-free longer.
- Naltrexone may reduce meth use and increase abstinence.
- Combined naltrexone plus bupropion (extended-release injectable naltrexone plus extended-release oral bupropion) is a promising treatment to reduce meth use but more study is needed.
- Methylphenidate and d-amphetamine show promise as substitution therapies (like methadone replacing heroin or nicotine gum for smoking). They lessen withdrawal symptoms and help people stay in treatment in longer.
Bupropion (Wellbutrin)
What it does: This antidepressant treats depression and nicotine dependence. It may also help treat low level dependence on meth.
How it works: Bupropion increases the natural brain chemicals dopamine and norepinephrine. Dopamine improves mood and norepinephrine improves mental clarity and focus.
Side effects: Dry mouth, headache, nausea and vomiting, dizziness. In early treatment, you may experience agitation, restlessness, and insomnia. It is better not to take it at bedtime which may help improve sleep.
For a more complete list of side effects visit this NIH page.
Availability: Physician prescription
Research Studies
Research Studies
A study on bupropion, 300 mg a day, showed it increased the number of weeks of abstinence in men with low to moderate meth dependence. Montoya ID 2008
Bupropion helped male patients who had a lower level of meth use. In these patients, bupropion combined with behavioral group therapy increased the number of weeks off meth. Elkashef A 2007.
For more information on Bupropion click here.
d‐amphetamine and methylphenidate
What it does: These central nervous system stimulants increases alertness, attention, energy, and physical activity. They are usually used to treat extreme sleepiness from a sleep disorder called narcolepsy or symptoms of ADHD (attention deficit disorder).
How it works: Dopamine is a natural brain chemical associated with pleasure, movement, and attention. Meth increases dopamine rapidly and intensely, producing euphoria and addiction. These stimulant medications increase dopamine slowly and steadily, similar to the way dopamine is naturally produced in the brain. Because of this they may be able to act as a potential substitute treatment for meth addiction.
Side effects: headache, dry mouth, constipation, weight loss, dizziness, nervousness, nausea
For a more complete list of side effects visit these NIH pages: methylphenidate and d-amphetamine.
Availability: Physician prescription
Research Studies
Research Studies
In this review of medication treatment for meth dependence, the most consistent positive findings were for d-amphetamine and methylphenidate, naltrexone and topiramate. Siefried KJ 2020.
A study of 60 people with meth dependence were given 60 mg of d-amphetamine for 8 weeks plus 8 sessions of psychotherapy. Although taking d‐amphetamine did not reduce use of meth, there were significant reductions in withdrawal and craving. More study is need to see if higher doses may be even more effective. Galloway 2011.
Two studies, one using d-amphetamine and the other using methylphenidate, have shown promise. Karila L 2010
Early pilot data are positive for the use of D-amphetamine and methylphenidate as a treatment for heavy methamphetamine users. Elkashef A 2008.
For more information on d-amphetamine click here
For more information on methylphenidate click here
GAMMA-VINYL-GABA (GVG) or VIGABATRIN (Sabril®)
What it does: These anticonvulsant drugs are used to control seizures. They may also reduce cravings for meth and other drugs.
How it works: Increases the amount of the natural chemical GABA in the brain, which lowers dopamine production. An appropriate dose of vigabatrin taken before exposure to nicotine, cocaine, meth or inhalants can block their effects on the brain.
Side effects: Sleepiness, dizziness, weakness, muscle pain, weight gain and shaking.
For a more complete list of side effects visit this NIH page.
Availability: Physician prescription
Research Studies
Research Studies
This small study looked at the safety and effectiveness of GVG (vigabatrin) for treating meth and/or cocaine addiction. Sixteen out of 18 people in the study tested negative for meth use during the last 6 weeks of the trial. GVG was found to be a successful and safe treatment for meth and/or cocaine addiction. Brodie JD 2005.
For more information on Vigabatrin click here.
Mirtazapine (Remeron)
What it does: An antidepressant found to decrease meth use. It helps calm cravings and reduces drug-seeking.
How it works: Helps release several natural brain chemicals including norepinephrine, serotonin and dopamine that are involved in mood.
Side effects: drowsiness, dizziness, anxiousness, confusion, increased weight and appetite
For a more complete list of side effects visit this NIH page.
Availability: Physician prescription
For more information on Mirtazapine click here.
Modafinil (Provigil®)
What it does: Modafinil promotes wakefulness. It may help ease withdrawal from meth and improve sleep, concentration and energy levels.
How it works: Changes the amounts of certain natural chemicals in the brain that control sleep and wakefulness. It may act as a stimulant which can decrease craving and meth seeking and improve mood. Its effects are long-lasting and continue for as long as four months after treatment.
Side effects: Headache, dizziness, drowsiness, nausea, constipation and heartburn
For a more complete list of side effects visit this NIH page.
Availability: Physician prescription
Research Studies
Research Studies
This study showed a trend favoring the use of modafinil in people who use meth often (more than 18 times in 30 days) and who did not regularly attend group counseling sessions. Further evaluation is warranted. Heinzerling KG 2010.
Modafinil reduced patient ratings of a “high” from meth and cravings for the drug by approximately 25%. Overall it did not cause serious side effects or discomfort. De La Garza R 2010.
Eighty meth users took either modafinil (200 mg a day) or placebo (a fake drug) for 10 weeks and were followed up 12 weeks later. Modafinil showed promise in reducing meth use in selected patients. Study findings support the need for larger studies. Shearer J 2009.
Modafinil was found to have multiple benefits. It may help treat mood changes from meth withdrawal; decrease withdrawal symptoms, craving and drug seeking; and improve people’s response to short-term mental health therapies. Montoya ID 2008
For more information: medlineplus.gov/druginfo/meds/a602016.html
For more information on Modafinil click here.
Naltrexone
What it does: Blocks opioid receptors in the brain from being turned on. Instead of controlling withdrawal and cravings, it prevents a drug from producing a high.
How it works: Blocks the part of your brain that feels pleasure when taking meth so you don’t feel the rush or high. It significantly reduces cravings by reducing meth’s rewarding effects and making it less pleasurable.
Side effects: Nausea, vomiting, diarrhea, constipation, headache, dizziness.
For a more complete list of side effects visit this NIH page.
Availability: Physician prescription
Research Studies
Research Studies
The first study in the U.S. on Naltrexone for people using meth found it was a very promising treatment. It significantly reduced the craving for meth and made users less aroused by it. Naltrexone had very minimal side effects. Further clinical studies are needed. Ray LA 2015.
In this review of medication for meth dependence, the most consistent positive findings were for d-amphetamine and methylphenidate, naltrexone and topiramate. Siefried KJ 2020.
For more information on Naltrexone click here.
Researchers continue to work on developing medications and new treatments for meth addiction, including vaccines and stimulation of the brain using magnetic fields (called Transcranial Magnetic Stimulation).
Our TREATMENT section has a broad range of recovery options to help you find treatments that best meet your needs. Also see our PROGRAMS & SUPPORT section for ongoing ways to support your recovery.
TOPIRAMATE
What it does: Topiramate is an anticonvulsant medication. When used in recovery, it may ease anxiety and agitation and help reduce cravings.
How it works: It decreases abnormal excitement in the brain. By reducing levels of the natural brain chemical dopamine which creates the feelings of pleasure and reward that people get from drugs, it may help reset the brain's chemistry
Side effects: Numbness and tingling in the hands and feet, difficulty concentrating, nervousness, headache, drowsiness and mood swings.
For a more complete list of side effects visit this NIH page.
Availability: Physician prescription
Research Studies
Research Studies
In this study of 140 meth users, topiramate did not lead to abstinence but did reduce the amount of meth taken and the relapse rates in those who were already abstinent. Elkashef A 2011
For more information on Topiramate click here.
Researchers continue to work on developing medications and new treatments for meth addiction, including vaccines and stimulation of the brain using magnetic fields (called Transcranial Magnetic Stimulation).